Differential expression of a novel ankyrin containing E3 ubiquitin- protein ligase, Hace1, in sporadic Wilms’ tumour versus normal kidney
نویسندگان
چکیده
Departments of Pathology and Pediatrics, British Columbia Research Institute for Children’s and Women’s Health, and the University of British Columbia, Vancouver, BC, Canada V5Z4H4; Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, IWK Grace Health Centre, Halifax, Nova Scotia, Canada B3L3G9; Cross Cancer Institute, Edmonton AB, Canada T6G1Z2; Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, V5Z4S6; Institute for Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
منابع مشابه
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.
We have analyzed the chromosome 6q21 breakpoint of a non-constitutional t(6;15)(q21;q21) rearrangement in sporadic Wilms' tumor. This identified a novel gene encoding a protein with six N-terminal ankyrin repeats linked to a C-terminal HECT ubiquitin-protein ligase domain. We therefore designated this gene HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1). HACE1 is...
متن کاملHACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1)
Anglesio et al. showed that a 4,6-kb transcript of HACE1 with strong expression in heart, brain, placenta, pancreas, as well as adult and fetal kidney. HACE1 expression is virtually undetectable in the SKNEP-1 Wilms' tumor cell line and in four of five additional primary Wilms' tumor cases compared with patient-matched normal kidney (Anglesio et al., 2004). Zhang et al. showed that HACE1 mRNA t...
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The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions. HACE1 is increased in the serum of patients with heart failure. Here we show that HACE1 protects the heart under pressure stress by controlling protein degradation. Hace1 deficiency in mice results in accelerated heart failure and increased mortality under haemodynamic stress. Hear...
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متن کاملAberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer.
BACKGROUND It has been recently reported that HACE1, the E3 ubiquitin ligase, is epigenetically inactivated in human Wilms' tumors and HACE1 expression was also down-regulated in colon carcinomas. MATERIALS AND METHODS The methylation status of the HACE1 gene was examined in primary carcinomas and the corresponding normal tissues derived from 32 patients with colorectal cancer using quantitat...
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